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Image Search Results
Journal: Frontiers in Cellular and Infection Microbiology
Article Title: Artemether, Artesunate, Arteannuin B, Echinatin, Licochalcone B and Andrographolide Effectively Inhibit SARS-CoV-2 and Related Viruses In Vitro
doi: 10.3389/fcimb.2021.680127
Figure Lengend Snippet: (A) Evaluation of anti-GX_P2V effect of monomer compounds extracted from traditional Chinese medicine. Vero E6 cells were infected with GX_P2V at an MOI of 0.01. Treating with 389 different kinds of monomer compounds in the “three formulas and three medicines”, the final concentration of each drug was 50 μM, and after 48 h, total RNA was extracted, and qRT-PCR was performed. The Y axis of the graph represents the average inhibition rate of the virus. The X-axis of the graph represents six drugs that have excellent anti-coronavirus activity. The experiments were done in triplicates. (B) EC 50 and CC 50 of six monomer compounds in “Three Medicines and Three Prescriptions”. Virus infection and drug treatment were performed as mentioned above. Among the drugs obtained in the preliminary screening, 6 drugs have excellent antiviral activity and low cytotoxicity, and have the potential to become specific drugs for the treatment of COVID-19. The experiments were done in triplicates.
Article Snippet: The
Techniques: Infection, Concentration Assay, Quantitative RT-PCR, Inhibition, Activity Assay